Biotechnology & Bioprocessing
In biotechnology, process stability and product integrity determine research success. Resato’s High Pressure Systems (HPP) support advanced biotechnology and bioprocessing research. Our specialized units are designed for precision and consistency, enabling advanced studies in cold sterilization of cell culture media, stabilization of sensitive fermentation products, and extraction of bioactive compounds under defined conditions.
Applications range from cultured meat and enzyme technology to natural extracts, all within a controlled high-pressure environment that supports reproducible results.
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Unlocking Biological Potential: HPP in Biotechnology
Our biotechnology-grade High Pressure Processing units are designed to meet the demanding requirements of R&D labs and pilot plants in the bioprocessing sector. With capabilities of up to 10,000 bar and a precise temperature range from -20°C to +100°C, Resato systems offer unparalleled control for critical research. This enables in-depth studies into preserving sensitive biological materials, modifying enzyme activity, and enhancing extraction yields, providing the perfect environment for every cycle with logged data for analysis and certification.
Cultured Meat & Cellular Agriculture
Cultured meat production depends on sterile, nutrient-rich cell culture media for reliable cell growth.Traditional heat sterilization methods can damage sensitive growth factors and proteins essential for cell proliferation. HPP uses high pressure instead of heat, inactivating microorganisms while preserving the 3D structure and biological activity of critical components such as insulin and transferrin. These systems enable scalable and safe media preparation, making them ideal for supporting innovation in the cultured meat industry.
Key benefits
- Growth factor preservation
Maintains biological activity of heat-sensitive growth factors. - Sterile media
Inactivates pathogens (bacteria, viruses, mycoplasma) without thermal degradation. - Enhanced cell viability
Supports robust cell growth and proliferation in culture. - Scalable solution
Enables efficient and safe preparation of large volumes of media.
High-Value Fermentation Products
Fermentation produces valuable ingredients like enzymes, vitamins, natural colorants, and specialty proteins. Stabilizing these compounds after fermentation is essential for their effectiveness and shelf life. HPP preserves sensitive ingredients by killing microbes without heat, protecting molecular integrity. Known as cold pasteurization, HPP prevents damage to fragile molecules and maintains biological activity in products like enzymes and vitamins. This technique ensures consistent quality and safety for fermentation-derived ingredients.
Key benefits
- Preserved bioactivity
Maintains molecular structure and function of enzymes and vitamins. - Cold pasteurization
Extends shelf life without thermal degradation. - Clean label processing
Reduces or eliminates the need for chemical preservatives. - Product stability
Ensures consistent quality and efficacy of fermentation-derived ingredients.
Enzyme Technology
Enzymes are indispensable catalysts in industrial biotechnology, driving countless biotransformations. HPP provides a unique tool for both fundamental and applied enzyme research. Pressure can induce conformational changes that modify enzyme activity and enhance operational stability, resulting in longer-lasting catalysts and lower production costs in large-scale bioprocesses. HPP has improved lactase stability in dairy processing, supporting more efficient lactose-free milk production. Resato’s precise HPP systems enable researchers to explore novel enzyme functions, optimize biocatalytic processes, such as proteases in food manufacturing or lipases in biofuel production, and develop more robust enzymes for industrial applications.
Key benefits
- Conformational control
Modifies enzyme structure to alter activity or specificity. - Enhanced biocatalysis
Optimizes reaction rates and yields for industrial processes. - Stability studies
Research into enzyme behavior under extreme conditions. - Novel enzyme development
Facilitates the creation of enzymes with tailored properties.
Bioactive Extraction
Efficient and gentle extraction of bioactive compounds from microbial or plant sources is essential for the nutraceutical, cosmetic, and pharmaceutical industries. HPP uses extreme pressure to rupture cell walls without heat, enabling controlled release of valuable intracellular compounds such as omega-3 fatty acids, antioxidants, and proteins. This non-thermal approach prevents oxidation and degradation, resulting in high-purity extracts with preserved biological activity while reducing the need for harsh solvents. HPP has been applied to extract astaxanthin from microalgae and polyphenols from plant materials, demonstrating its value across these sectors.
Key benefits
- High-quality extracts
Preserves purity and biological activity of sensitive compounds. - Efficient cell disruption
Maximizes yield of intracellular bioactives. - Non-thermal process
Prevents degradation and oxidation during extraction. - Sustainable extraction
Reduces reliance on organic solvents, promoting greener processes.
Interested in HPP for Biotechnology Innovations? Contact Resato
Do you want to push the boundaries in cultured meat, high-value fermentation, enzyme technology, or bioactive extraction with HPP technology? Resato supports you in finding the right solution for you, specifically tailored to your research requirements. Contact Resato for more information or receive a custom solution. Our team is ready to advise you on your needs to unlock new biological potential.
Our team is ready to offer you advice customized to your needs.